Arsenal and Arsene Wenger, the Arsenal manager, said at the press conference on Thursday that "this is a very important game. For us, we want to get the three points in order to improve our ranking in the tournament. "
"Tottenham are a good team, but we have a way to win this game," Wenger said.
Tottenham have a long hand in the two sides, keeping their record unbeaten in their last six matches.
Despite a 1-1 draw in his last three visits to the Emirates, Tottenham have only one win on the pitch, which has played 11 league games since it was officially opened in 2006.
"I can not say I've won this field before, but that's what we're going to do on Saturday," said Tottenham defender Jan Verteachen.
"The meetings between the two teams are always strong, positive and mutual respect," he said. "Both teams are positive, which makes their matches good."
Tottenham Hotspur striker Harry Kane is expected to take part in the match after recovering from a recent knee injury and being denied entry to England in his friendly matches on the international agenda.
Kane has scored six goals in the last five encounters between Tottenham and Arsenal.
Wenger said doubts about his French striker Olivier Giroux were in doubt after he was injured during his friendly win over Wales in the middle of the week.
For their part, Manchester City look forward to continuing their series of victories, when they take on Leicester City tomorrow.
City have won all of their last 10 games in the tournament, scoring 35 goals, leading them solo.
City coach Josep Guardiola is in the final position for Argentinian striker Sergio Aguero, who suffered a fainting spell during the break during his friendly against Nigeria on Tuesday.
Second-placed Manchester City, eight points behind City, are hoping to regain their balance after losing 1-0 to Chelsea in the last stage when they host Newcastle United on the same day.
"We hope to show up well and score the three points and keep showing our strength at Old Trafford as we have so far," United midfielder Juan Mata wrote on his weekly blog.
"It is a key factor in maintaining our position in the conflict of progress," Mata said.
Chelsea, who are fourth on 22 points, are looking for a fourth consecutive win when they face West Bromwich Albion, while fifth-placed Liverpool face Southampton.
West Ham United are due to meet Watford on Sunday in the first appearance of new coach David Moyes, who took over as Croatian coach Slavin Bilic.
West Ham, who are 18th on the bottom of the game, have a defensive edge after conceding 23 goals in 11 games.
"We've been looking at the goals we've been hit by," Moyes said. Unfortunately, we have the worst defensive line in the tournament now. "
"We should try to find a way to stop it."
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